4/7/2024 0 Comments For if loop in r![]() ![]() ![]() ![]() R-loop-induced genomic stress is directly linked with failure to remove the R-loops in a timely manner 5, 6. Paradoxically, R-loops were long considered detrimental byproducts of transcription that interfere with transcription 4 and contribute to genome instability. RNA–DNA hybrids and R-loops have recently gained attention for having important roles in cellular processes such as gene regulation and DNA repair 2, 3. When the formation of an RNA–DNA hybrid results in the displacement of single stranded DNA (ssDNA) it is referred to as an R-loop. The term RNA–DNA hybrid refers to base-pairing of RNA with DNA. One mode of how RNA may exert regulatory functions in the genome, in a sequence specific manner, is through the formation of RNA–DNA hybrids. Although the biology of some non-coding RNAs (ncRNAs) is fairly well established, an understanding of the regulatory functions of other ncRNAs remains preliminary or elusive. Primarily through using next-generation sequencing, it has been recognized that a large part of the genome is transcribed and that there are countless RNAs of different lengths with potential regulatory functions 1. The past decade has revolutionized our thinking about regulatory RNAs. ![]()
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